I personally think Orgy Den Smoke Out is a really good turn 0 play. Mainly because your opponent has to discard a card at random from their hand, which after they've mulliganed to get a hand their comfortable with, can be quite annoying. Plus, with the mill 2 cards ability, you're already 3/4 of the way to playing a Swashbuckler.
turn 0: Smoke Out
turn 1: Card Counter/Defenestrate/Tremor Engine/Heist Planner
turn 2: Swashbuckler. 4/4/4 on turn 2 is pretty solid
It also helps guarantee that you'll have a better chance of being abe to Scrag your opponent's bigger guys, eventually.
"You know, if you stab a man in the dead of winter, steam will rise up from the wounds. Indians believed it was his soul escaping from his body."
Al Bundy - Wayne's World